







🐕🦺 Keep calm and carry on—because your pet deserves zen every day!
Vetoquinol Zylkene is a 75mg daily calming supplement for small dogs and cats, featuring alpha-casozepine, a natural milk protein that promotes relaxation without sedation. Lactose-free and vet-recommended, it supports pets through stressors like travel, vet visits, and loud noises, while being gentle on sensitive stomachs and easy to administer by mixing into food.












































| ASIN | B01M0P5SMW |
| Active Ingredients | Active Ingredients: Hydrolyzed Milk Protein (Bovine): 75 mg (providing alpha-casozepine) |
| Best Sellers Rank | #3,047 in Pet Supplies ( See Top 100 in Pet Supplies ) #161 in Cat Relaxants |
| Brand | Vetoquinol |
| Brand Name | Vetoquinol |
| Customer Reviews | 4.1 out of 5 stars 3,648 Reviews |
| Dog Breed Size | Small |
| Flavor | Milk |
| Item Form | Capsule |
| Item Weight | 0.09 Ounces |
| Manufacturer | Vetoquinol |
| Manufacturer Part Number | 14859731 |
| Model Number | 14859731 |
| Number of Items | 1 |
| Specific Uses For Product | anxiety, moving, stress, thunderstorms |
| Target Species | Dog |
| UPC | 802691369288 |
| Unit Count | 14.00 Count |
A**R
Anxiety Ridden Cat Approved for marking!
My kitty Goose is the only one of 4 indoor cats we have that has had a terrible problem of marking (he’s 10 this year and this began 2 years ago) in one room of the house. Same spot over and over, no amount of enzyme cleaner or cleaning of the area and direct spot cleaning has made him stop. I was at my wits end and didn’t know what other steps to take, before going to the vet (he has been cleared of any medical complications) for prescribed medication, I figured I’d give this a shot. I give him one pill in the morning mixed with a quarter of his squeezable treat and he has completely stopped, he is much calmer overall, and actually seems at peace now. There are no side affects aside from the first dose where he literally looked like he was stoned for about an hour lmfao that has since stopped, and he acts completely normal after his dose (for his weight is recommended two, I only give him one) and he doesn’t notice any taste or smell from it, he gets excited when I shake the bottle in the mornings to mix it for him! I highly recommend this product for people struggling with a cat who has high anxiety or marking issues! From a very relieved cat mom who was ready to throw in the towel.
W**Y
Works very well!
It took a week or so but my 17 yea old cat with dementia and other illnesses calmed down. He had been up all night, yowling and walking up and down our bed multiple times. Now he seems much more comfortable and able to relax at night. It’s not 100% but way better than before. I have to put it in a pill popper to give it to him but you could open the capsule and sprinkle on food.
A**A
Effective for calming.
I find this good for calming. It’s hard to say if this alone is helping but I do see a difference. It helps if it’s taken daily rather than as needed. It’s expensive so taking off one star.
Z**E
Worked amazing
Amazing
D**R
Decent product but the constant price increases force me to look for alternatives
I have a small terrier with allergies and anxiety. For her to be happy, I have to manage both. This product does a good job of relaxing her, though it is not the only thing I use. I do notice when I stop using it she is antsier, so I have chosen to continue the product. But the price continues to increase from expensive to untenable. I looked around for alternatives. The active ingredient is called Alpha-Casozepine, according to the label. So, in looking for products with this, it turns out that Lactium is a trademarked version of this. It was difficult to find a product with this alone. Ultimately, I found a Swanson Antistress human product that contained only this as an active ingredient. There are other products that have this ingredient along with other things that I didn't want. I'll see how this new product works once I receive it. Interestingly, Calmkeen, a product that markets itself as similar, has hydrolyzed milk protein as the active ingredient, but it does does not have the actual Alpha-Casozepine. I bought it to alternate with Zylkene, but it simply does not work as well for my dog. And the price, which is significantly cheaper than Zylkene, has continued to rise likely because Zylkene's has. Anyway, if money is no option, then Zylkene is an effective product. If you don't want to continue to pay chronic price increases, you may need to look for an alternative.
J**.
Decided to revisit this and try it out again
Update 2 months: This is absolutely necessary to keep the peace in my household. I have started to give her slightly more than 75mg, because it wasn’t working as well after a while but giving her 1 pill plus a little sprinkle from the second pill works great. She is just over the weight suggested for the 75mg. I tried to give it every other day but it just was not working as well as every day. We still smoosh it into a few pill pockets and make like a dough and then I pinch off treat size pieces and she loves it! She cries for it every morning and that is what she wants for breakfast lol. She’s now refusing wet food because this is what she wants. Update 7 days after initial review: I have been giving 1/2 of a 75mg capsule twice a day to my cat for 7 days straight now and she has not attacked my other cat in 7 days! We usually have stalking and attacking constantly so to go from constantly to none is very impressive! What I really like is that she still has her personality and does not seem drugged in any way. She just isn’t a psychopath stalker anymore 🤷🏻♀️. I plan on continuing the regimen and giving 1/2 to her twice a day. I started by sprinkling half a capsule on her wet food but she doesn’t eat all of it (she doesn’t mind the powder at all) so instead I have been buying pill pockets and I just knead it into the pill pocket like a dough and she eats it right up. This way she gets the full dose and I’m not wasting any. Initial review: My vet recommended that I try this before we put my cat on Prozac. I have two cats. My cats are not litter mates, they are both 6 years old and I adopted them one year apart. Pandora was the second cat I adopted and she has turned out to be a little psychopath. She constantly bullies and stalks and chases and attacks my other cat. It drives me insane and at times it’s extremely draining. I have tried very good quality lab tested CBD, and every kind of feliway spray and diffuser there is. Nothing works. I purchased this about 8 months ago and the first time I gave it to her she full on attacked my foot (not playing, it was very aggressive) and she has never done that before. So I have not given it to her again. Out of desperation, I am revisiting this option, after reading more about how to administer, I think she probably just needs more time to adjust. I sprinkled half of one capsule on top of about a tablespoon of wet food. She ate almost all of it right away. I purchased some pill pockets and I think I can smush the powder into them and feed it to her that way to ensure she gets as much of the product as possible without wasting any. She goes crazy for pill pockets! I’ll gladly update this review once we finish the bottle. Tonight was the first night we started it again and she walked around the house looking for something to get into for about 30 minutes (typical) and then laid down and went to sleep.
L**N
My picky cat Approves of the flavor
I got a small box of this first out of concerns my very picky cat wouldn’t like the powder mixed in with his food. He barely likes snacks. Well- he loved it- so I’ll be buying larger quantities in the future. I think it’s helping with his anxiety as well which was the purpose of buying it. Only downside is the price.
M**S
Worked for a while
Worked for a while till my cat got used to it. I used to mix it in her food and give it to her as needed. This was recommended by her vet but no longer works, she now requires something else.
C**Y
For first year dog not really can’t help
All in good condition.
Trustpilot
3 weeks ago
1 day ago