









🐕🦺✨ Elevate your pet’s skin care game with vet-trusted antiseptic hydration!
S3 Pyo Shampoo is a 6.7 fl. oz. antiseptic and hydrating shampoo formulated with 3% Chlorhexidine and 0.5% Ophytrium. Designed for dogs and cats, it effectively combats bacterial and yeast skin infections while supporting the skin’s natural barrier. Free from harsh chemicals, it’s the top non-prescription choice recommended by U.S. veterinarians to soothe, moisturize, and protect sensitive skin.





| ASIN | B0947674MT |
| ASIN | B0947674MT |
| Age Range Description | All Life Stages |
| Allergen Information | Hypoallergenic |
| Best Sellers Rank | #402 in Pet Supplies ( See Top 100 in Pet Supplies ) #3 in Dog Shampoos |
| Brand Name | Douxo |
| Color | Translucent |
| Customer Reviews | 4.7 4.7 out of 5 stars (6,839) |
| Date First Available | May 5, 2021 |
| Date First Available | May 5, 2021 |
| Directions | Use as recommended by your veterinarian. Wet the fur with cool water from the neck down. Using 1 pump for every 4 lbs, gently massage shampoo onto skin abnormalities to reach the skin. Repeat until entire body is lightly coated with shampoo and leave on for 10 minutes. Rinse thoroughly with cool water. Shampoo amount can be doubled for dogs or cats with long and/or thick fur. |
| Included Components | Shampoo |
| Item Package Dimensions L x W x H | 5.94 x 2.48 x 1.81 inches |
| Item Weight | 6.7 Ounces |
| Item model number | D98410M |
| Item model number | D98410M |
| Liquid Volume | 6.7 Fluid Ounces |
| Manufacturer | Douxo S3 |
| Manufacturer | Douxo S3 |
| Model Name | PYO |
| Number of Items | 1 |
| Package Dimensions | 5.94 x 2.48 x 1.81 inches; 6.7 ounces |
| Size | 6.7 oz |
| Special Ingredients | ophytrium |
| Specific Uses for Product | Coat, Skin |
| Target Audience Keyword | Cats, Dogs, dogs |
| Target Species | dog, cat |
| UPC | 850002593426 |
T**S
Amazing Stuff - fixed my dog's skin issues!
My dog had maybe a yeast infection, skin allergies... idk. He had scabs and dandruff all over his back and belly, and lots of discoloration on his belly which came out of nowhere, He was constantly itching and I felt so bad for him ): I decided to look into it and found people with similar issues. So, with recommendations, I found this shampoo, and also switched his dog food to a better one. With the switch of his dog food, I can't say that one or the other fixed his skin, or both was the solution, but either way, his skin and coat has made a DRASTIC change in just one month. I have been washing him every 3-4 days with this shampoo for a month now, scrubbing him very well and leaving it to sit on him for 5-10 mins. He hates baths but it's what we have to do! This stuff smells great, it suds up and has a nice lather, rinses well, and leaves his coat feeling soft and clean! I can't complain at all. Yes it is pricey as heck, but if it works how can I complain. when I was researching on the internet for my dog's specific issues, I saw people with similar issues say their dog had a yeast infection, and when they took their dog to the vet, this is what their vet recommended! This is what made me take the jump on the purchase and I was not disappointed.
H**R
5 Stars - HIGHLY Recommend! Works Amazing for Allergies!
Hands down the best dog shampoo I've ever used.y American Pitbull is allergic to everything,I even had him undergo the prick test with the Dermatologist & he's allergic to 40 out of 46 items tested for. So his skin is always broken out, even while doing the Allergy Immunotherapy injections, I'm averaging every 3rd day on giving him another bath & this shampoo is helping him so much! He will be completely broken out, red bumps & hives all over his body, I'll give him a bath & within a few hours, or by the next morning (since I usually bathe right before bed) his skin has significantly improved, half the bumps will be gone, most of the hives are completely gone & the redness is nonexistent! The smell is really great as well, it's a lighter scent, I don't smell any chemicals or any of the normal medicated smell at all & it's light enough you can smell it on your pup if you're up close, but otherwise it's not noticeable. The formula is decently thick, it's not runny at all, but it suds up so great as well - another huge thing most medicated shampoos don't do! You also only need a small amount, it actually advises how much to use on the bottle depending on how large your dog is, but it's so easy to suds up, that you don't need much at all. I have a 64lbs Pitbull & I only use 2 pumps on his whole back, 1 on each side & 1 pump on each leg & that's about it. So the cost is a bit expensive, but it lasts forever with how little you need & with how well it works, its 100% worth it. The pump works great, it has the locking mechanism when you turn the pump to the side, so you don't have to worry about it leaking, we transport it every weekend to our MIL's house, and I just throw it in the bag, never leaked before, you don't have to worry about it. I can't recommend this shampoo enough or stress how well its been working for our 4 dogs!
B**R
Works well!!
This is a great shampoo for my maltipoo. It smells nice and decreases his itchiness.
S**A
Excellent result
I liked it very much, the result on my dog's skin, it felt much less itchy, after using it.
S**M
Worth EVERY Penny
This shampoo has been an absolute game-changer for my dog. She’s 13 years old now and has struggled with itching her entire life. We’ve tried just about everything over the years—multiple prescriptions, countless vet-recommended products, and so many over-the-counter solutions. Nothing ever gave her real relief until we started using this shampoo along with the mousse. The difference has been incredible. She used to spend her days constantly scratching and licking, and nights were often the worst—waking up itching, sometimes even crying out in discomfort. It was heartbreaking to watch. Since switching to this product she’s finally comfortable. She sleeps peacefully through the night now, complete with the sweetest little snores, and during the day she’s relaxed instead of restless. It’s been amazing to see her quality of life improve so dramatically. I’ve been using this consistently for months and I’m a repeat purchaser—I’ll never be without it. It not only calms her skin but also keeps her coat soft, clean, and so fresh smelling. I did find that buying directly from the company offers a better price, but regardless, this shampoo (and mousse) are worth every penny. If you have a dog struggling with chronic itching or irritated skin, I can’t recommend this product enough. It has truly been the only thing that has worked for us after years of searching, and it’s given my dog the comfort she deserves.
K**C
Great for dogs with skin allergies or regular use
We have been using this product for years. Initially started when our Doberman had severe skin allergies requiring shots and steroids. Now we use for our lab. It does take extra time as they suggest leaving the product on during the bath to get the best impact for the skin. There is not a strong smell and the dog smells good after the bath. It works very well and lasts long. It significantly has reduced skin irritation.
M**S
Great for treating Domadex in dogs.
Purchased to treat my Boston Terriers Domadex skin issues. Noticed an improvement within a week of bathing them every other day. I use this regularly now to help control skin irritation and itching. Great shampoo.
D**A
Helped with my dog’s paw yeast infection. Stopped the itching and redness.
M**A
EXCELENTE PRODUCTO, TENGO UNA BEAGLE CON SINDROME DE CUSHING + DERMATITIS ATOPICA, ASÍ QUE ES MUY COMÚN QUE RECAIGA EN SUS PROBLEMAS DE PIEL, CON ESTE SHAMPOO SUS PROBLEMAS HAN DISMINUIDO UN 80%, HE UTILIZADO MÁS DE 15 SHAMPOOS (SIN EXAGERAR) Y ESTE HA SIDO EL QUE MEJOR LE HA FUNCIONADO Y DISMINUIDO SUS BROTES EN LA PIEL, VALE LA PENA CADA PESO INVERTIDO EN ESTE SHAMPOO.
A**A
les deja el pelaje suavecito y limpio
M**N
Exactly as described. Beautiful scent and a little amount goes a long way. Love it.
S**O
This shampoo will make your pet fur so soft and shiny . And the best part is reduce her dander by 75% … she is more calm now .. less scratchy. Since we live in humid so I shower her every 4 - 5 days .
Trustpilot
2 weeks ago
1 month ago