any legitimate research on this product?

No, there is not. There probably will be in the future though, and there is good reason to think that these kinds of products could be helpful for certain diseases though. This WSJ article is provides a good review on the subject: http://www.wsj.com/articles/SB10001424127887324557804578376562539148102. These things are unlikely to be harmful though, so it may be worth trying and seeing if it works for you. The only reason this supplement would work is if you don't produce enough enzymes on your own, which can happen in response to a bunch of different diseases. Also, 'legitimate research' would be any well controlled research rigorously executed with a large enough sample size, it would almost certainly come from an academic institution and be published in a peer reviewed journal. As Michelle points out, research by the makers of these supplements is unlikely to be 'legitimate', as they are incentivized not to control for placebo.

what's the difference between this and the plain Similase?

The Similase physician-developed formula provides excellent digestive support of carbohydrate, protein, fat, fiber, and phytate under virtually all gastrointestinal pH conditions. Similase helps relieve occasional indigestion, gas, and bloating, and provides comprehensive support for digestion and assimilation of nutrients from the diet. Similase serves as the foundation for more targeted formulas in the Similase line including the Similase GFCF. The Similase GFCF takes into account the digestion of gluten and casein that can be particularly difficult for some individuals and is gluten free while the Similase is not gluten free. Similase GFCF provides enzymes to support comprehensive digestive health, while also featuring superior dipeptidyl peptidase IV (DPP IV) activity for the digestion of proline-containing dipeptides from gluten and casein. Similase GFCF supports a gluten-free, casein-free lifestyle and helps relieve occasional indigestion, gas, and bloating.

Does this product contain milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, or gluten?

Integrative Therapeutics - Similase GFCF does not contain milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soy, tree nuts, wheat, or gluten. However it does contain yeast.

Does this product contain milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, or gluten?

Similase® GFCF Supplement Facts:2 Veg Caps contain:Plant Enzymes (543mg) of:DPP IV Protease Blend (Protease I,II,III,IV,V) :Assay Method---FCC (pH 4.7) 134,600HUT---FCC (pH 7.0) 22,660PC---USP (pH 7.5) 12,556USPAmylase :Assay Method---FCC (pH 4.8) 9,530DU---USP (pH 6.8) 12,800USPLipase I,II :Assay Method---FCC (pH 6.5) 408LU---FIP (pH 7.0) 882FIPPhytase :Assay Method---Phytic Acid (pH 6.0) 0.67PULactase I,II :Assay Method---FCC (pH 4.5) 642ALUCellulase I, II :Assay Method---FCC (pH 4.5) 141CUSucrase (Invertase) :Assay Method---FCC (pH 4.6) 119INVUOther Ingredients: cellulose, vegetable capsule (modified cellulose), inulin (from chicory root), and silicon dioxide.Contains NO: sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, preservatives or ingredients of animal origin. It does not mention the exclusion of nuts but it does not show any in the ingredient list and Integrative Therapeutics is usually good about listing any known allergens...especially one like peanuts/nuts

Similase GFCF - Digestive Enzyme Supplement for Adults - Supports Casein & Gluten Digestion* - Gas & Bloating Support* - Dairy-Free & Vegan - 120 Count (60 Servings)

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