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Medicube Exosome Shot Zero 2,000 PPM is a cutting-edge Korean liquid skin booster serum featuring 15 million patented exosome-coated spicules that deliver active ingredients deep into pores. Its advanced formula combines AHA, BHA, and PHA acids for gentle exfoliation, while niacinamide and panthenol enhance hydration and skin barrier health. Clinically tested and suitable for all skin types, this serum offers superior absorption—242% more effective than standalone treatments—resulting in smoother, revitalized skin with minimal irritation.



























| ASIN | B0D16L5F2M |
| Best Sellers Rank | #55 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #5 in Facial Serums |
| Brand | medicube |
| Brand Name | medicube |
| Customer Reviews | 4.5 out of 5 stars 2,951 Reviews |
| Item Form | Ampoule |
| Item Volume | 0.4 Kilograms |
| Item Weight | 30 Milligrams |
| Manufacturer | Medicube |
| Manufacturer Part Number | PMEKR14036 |
| Model Number | 8809981334928 |
| Number of Items | 1 |
| Product Benefits | Blemishes Treatment |
| Recommended Uses For Product | Dead Skin Cells,Skin Texture |
| Scent | Aloe |
| Scent Name | Aloe |
| Skin Tone | All |
| Skin Type | All, Combination, Dry, Oily, Oily Acne Prone, Sensitive |
| Special Ingredients | alpha_hydroxy, collagen, minerals |
| Target Use Body Part | Face |
| Unit Count | 1.01 Fluid Ounces |
| Use for | Face |
M**E
I was nervous to try, but it's so mild!
I was nervous to try this because of the spicules, since I’ve never used a spicule based product before. I chose the 2000 PPM Exosome Shot to start on the gentler side, and I was pleasantly surprised by how mild it actually feels on the skin. I use this once a week after cleansing (about two pumps), gently pat it in, and then follow with my nighttime moisturizer. There is a very slight pokey sensation on application, but it’s not painful or irritating- just noticeable enough to know it’s there. By morning, my skin looks noticeably smoother, more refined, and almost glass-like. I have reactive, eczema-prone skin, so I’m usually very cautious with exfoliating products and anything containing acids. Despite the AHA + BHA + PHA blend and spicules, I have not experienced dryness, itching, or sensitivity with weekly use. The exfoliation feels effective, but not harsh or barrier stripping. I also like that the formula includes niacinamide and soothing components alongside the exfoliants, which likely help balance the overall results. The texture is lightweight, spreads easily, and layers well with other skincare without pilling or being sticky. Overall, this is a great entry level spicule serum if you’re curious but hesitant. It delivers smoother, more refined looking skin texture without the aggressive irritation I anticipated. I will likely continue with the 2000 PPM for maintenance, and may consider trying the higher strength once my skin fully acclimates.
T**A
Gentle exfoliation that makes my skin look brighter and healthier
It's like a gentle micro needle that exfoliates my skin. I gotta love the medicube exosome shots because it makes my skin even out over time. Absorb immediately onto my skin and the results it's within weeks.
K**E
Very Good. Not a "beginner strength" product. Prepare for prickling.
If you're familiar at all with microneedling, this is the same idea. There are little spicy led (to y dissolving needles) in this serum that make micro channels in your skin to allow products to penetrate more deeply. It also has three gentle chemical exfoliants to smooth and brighten skin. It's a fairly thick, non-sticky serum, and it prickles quite a bit when you massage it in. I bought this on a whim and found out later that this is NOT "beginner strength". A starter serum would be a 100 ppm level. 2000 is definitely more intense and I do get some irritation immediately afterward. I own a professional grade microneedling machine, but between setting it up and sterilizing, it just feels like more of a project than I want to do for shallow, frequent needling. This serum is a nice shortcut and really, really speeds up the results I see from other products, and I use it roughly o CD a week.
M**H
Fast Results, But This Stuff Is Strong!
“I’ve been using Medicube for about a week and wanted to give a real, honest review. The first few days, my skin looked AMAZING super smooth, soft, and noticeably more glowy. I was really impressed with how quickly I saw results. I’ve used the exosome shot twice so far. After the second use, I did notice a few small breakouts and some redness, but they were in my normal breakout areas and not severe. From my experience, this seems more like an adjustment phase rather than a bad reaction. This is definitely a stronger product, so I would recommend starting slow and not overusing it. Overall, my skin still feels healthy, and I’m excited to see the long-term results once everything settles. If you have sensitive skin, just ease into it but so far, I do think it’s worth trying!”
R**E
Early-impressions review
I’ve recently started using the this Serum, so this is more of an early-impressions review rather than a full verdict. So far, I really like the texture and how quickly it absorbs into the skin. It doesn’t feel heavy or greasy, and it layers nicely with the rest of my evening routine. When I apply it, I notice a mild tingling sensation, almost like a gentle nettle tickle, but it doesn’t burn or irritate my skin, which is reassuring for a retinol product. I haven’t used it long enough to comment on visible results yet. With retinol products, I know it usually takes at least two weeks or sometimes longer to start noticing improvements in skin texture or fine lines. For now, I’m focused on how my skin tolerates it, and so far the experience has been comfortable and promising.
J**K
Revitalize Your Skin with a Boost of Confidence
I've tried a fair share of serums in my quest for smooth, even skin, but this liquid skin booster is a standout. It’s like a mini-facial in a bottle, designed to breathe new life into tired, uneven skin. The moment I started using it, I noticed an improvement in my skin texture and tone, especially around those pesky pores that always seem to hog the spotlight. The micro-sized, needle-like design is a fascinating touch, ensuring that the active ingredients dive right into my skin where they're needed most. With an impressive 15M patented exosome shots, this serum delivers a powerhouse of goodness directly to my pores. My skin feels more energized and vibrant, which is a delightful change from the dullness I was used to. Plus, the inclusion of AHA, BHA, and PHA means it's tackling dead skin cells head-on, leaving my complexion looking fresher than ever. What I love most is how the serum feels on my skin—it absorbs quickly without leaving any sticky residue, thanks to the superior absorption technology. Ingredients like Niacinamide and Panthenol not only boost hydration but also fortify my skin barrier, making my skin feel as supple as it looks. It's a comforting thought to know that this serum is clinically proven and gentle enough for sensitive skin like mine, free from any artificial nasties. Integrating it into my skincare routine was a breeze. The simple three-step process fits seamlessly into my day, and I can genuinely say it feels like I’m giving my skin a treat every time I use it. Whether you’re looking to refine your pores or just want to add a little extra glow to your routine, this serum might just be the secret weapon you’ve been searching for.
A**R
Slightly irritating, not sure about the spicules over long term
I like medicube serums and skincare products and I have tried medicube toner pads which I liked and a moisturizer which I also liked. This is my first time trying spicules so I went easy and I did a test spot on my inner arm. I did not have a reaction, but my arm felt hyper sensitive for a few hours. This absorbed quickly, stayed a little tacky which I wasn’t too excited about but it’s doable if it works. I patch tested on my chin and I did not get a reaction. I am going to use this on my chest and for spot treatment because I am still a little concerned about teeny tiny particles going into my skin…. Look what happened with hyaluronic acid filler that everyone though was a great skin plumper—- I’m going to go easy with this..
O**A
AMAZING
I absolutely love this exosome serum! It’s one of the most innovative products I’ve used, the texture feels lightweight and absorbs quickly without leaving any sticky residue. The formula combines exfoliating acids (AHA, BHA & PHA) with spicule technology and exosomes that really help refine texture, clarify pores, and promote smoother, healthier‑looking skin. I noticed my skin looked softer and more radiant with continued use, and my other skincare products seemed to absorb better afterward. It does give a noticeable tingling or prickly sensation on application (which is normal for this type of serum), so if you’re new to actives or have very sensitive skin, start slowly — but for me the results have been worth it. Overall, this serum has earned a permanent spot in my routine!
H**T
Top
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D**.
Unbelievable
I swear for the price and the effect it shows 10/10. Tbh I didn’t expect much from this all I know it’s that it kinda hurts and it replicates microblading but at home version so I got it. But I swear I’ve been using it as a night time routine and my dark spots is becoming lighter and lighter! I had this a HUGE dark pigmented spot on my cheek due to a pimple (literally every pimple I get leave a dark mark on my face it’s so annoying) anyways it’s now fading!!!!!! And what I got this product 2 weeks ago?? Fabulous. Definitely give it a go
J**A
Pica un poco en la piel
Tengo poco usándolo,pero sí pica cuando lo uso. Espero cumpla su función
A**R
Good
Nice product
R**A
Product dat werkt voor mijn huid
Mijn huid voelt zacht aan en niet vettig
Trustpilot
2 weeks ago
1 month ago