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💥 Elevate your cellular game — because peak performance waits for no one!
TMG Methylation Essentials delivers a potent 900mg dose of Trimethylglycine per serving, combined with essential cofactors B12, B6, Folate, and Zinc to optimize methylation pathways. Its acid-resistant enteric capsules ensure superior absorption in the small intestine, supporting DNA protection, healthy aging, and cognitive function. Made in the USA in a GMP and FDA-registered facility, this third-party tested supplement offers a clean, vegetarian formula designed for professionals seeking a scientifically backed edge in cellular health.




| ASIN | B0CXBZ7JN3 |
| Age Range Description | Adult |
| Best Sellers Rank | #95,881 in Health & Household ( See Top 100 in Health & Household ) #380 in Vitamin B12 Supplements |
| Brand | Renue By Science |
| Brand Name | Renue By Science |
| Container Type | Bottle |
| Customer Reviews | 4.3 out of 5 stars 63 Reviews |
| Diet Type | Vegetarian |
| Dosage Form | Capsule |
| Flavor | Unflavored |
| Item Dimensions | 2.36 x 2.36 x 4.33 inches |
| Item Form | Capsule |
| Item Weight | 0.1 Kilograms |
| Manufacturer | Renue By Science |
| Manufacturer Part Number | 850055685062 |
| Number of Items | 1 |
| Primary Supplement Type | Zinc |
| UPC | 850055685062 |
| Unit Count | 120.00 Count |
J**O
What a difference
This is the best supplement iv ever used. You rarely take a supplement that you can FEEL makes a difference in a week/day This is absolutely one of them. From athletic performance to just day to day cognitive performance
E**P
This product is ideal for anyone looking to support their methylation processes
Upon receiving the TMG Methylation Essentials by Renue By Science, my first impression was of the clean, professional packaging that exudes quality and reliability. Opening the bottle, the capsules are standard size, easy to swallow, and thankfully unflavored, which is a huge plus for those sensitive to taste. The product boasts an impressive combination of essential nutrients: 900 mg of TMG, 12 mg of Zinc, 1000 mcg of Folate, 30 mcg of B12, and 5.1 mcg of B6 per serving. These ingredients are designed to support optimal methylation, a crucial process for cellular function and healthy aging. The acid-resistant enteric capsules are a thoughtful touch, ensuring the nutrients are absorbed effectively by surviving the stomach’s acidity. Using the product for a few weeks, I noticed a subtle but positive impact on my overall energy levels and mental clarity, which I attribute to the enhanced cellular function and DNA protection the product promises. Compared to similar supplements, TMG Methylation Essentials stands out due to its comprehensive formulation and the high quality of its components. The main downside is the need to take two capsules per serving, which might be a slight inconvenience for those who prefer a single-pill solution. However, considering the benefits and the quality of the ingredients, this is a minor issue. In terms of value for money, it’s priced reasonably given the superior formulation and the rigorous manufacturing standards (GMP compliant and FDA registered facility). This product is ideal for anyone looking to support their methylation processes, particularly those interested in boosting cellular health and aging gracefully.
T**S
Good product and price
I am new to the TMG part of this supplement but the rest of it, I already take on a daily basis. The recommended dose is 2 capsules per day and there are 120 capsules in the bottle, making this bottle last about 2 months. Currently, the pills are about 26 cents each so not too expensive per day if you take the recommended dose. Mine are fresh as they were manufactured in 2024 but I don't see the best by date on my bottle. I like that it has a flip top lid, but I don't have little ones at home to worry about getting into my pills. The capsules are fairly small and easy to swallow. They have no taste or odor. I would get them again if I continue to like the TMG aspect of this capsule.
S**L
Product is manufactured in USA using GMP standards
Dietary supplements, such as this Renue By Science TMG Methylation Essentials (Trimethylglycine) are not subject to FDA testing or certification. Because of that, it's up to the customers to do some research on the company they are buying from. I did my standard check on the product, by checking that the packaging is of high quality. This one passes with flying colors. Everything is properly labeled on the outside of the package, and the inner safety seal was properly applied. When I opened the safety seal I was not met with any strong smell. No smell at all. That's a good thing. The capsules are of normal size that I had no trouble swallowing. I've taken two capsules per day for the last two days with no adverse effects. I'll have to keep taking them for a bit longer before I will know if they are doing any good. The rest of the company history looks good. They have been in business since 2009 and the Better Business Bureau in their home city of Jacksonville FL has had 4 complaints on them in all that time. That's not very many. The company responded to all four complaints. There was only one complaint that involved an adverse reaction to the product, and that was a face cream, not a capsule that you swallow. The other complaints were involving shipping issues or a missing product accessory. My criteria for using a dietary supplement is that the company has to adhere to the packaging safety standards and have a good reputation. Renue By Science meets those qualifications , which is why I've been taking their capsules for the last two days and will continue to do, so I can tell if they give me positive results. My plan is to revisit this review once I've been on the capsules for a few weeks at least.
F**Y
Energized
TMG may help to protect both the liver and cardiovascular systems. While still a newer addition to my regimen, TMG seems to support the energy boost benefits touted for this supplement. I am using in conjunction with “Natures Craft Store Ox Bile Salts for Gallbladder Support - Purified Bile Salts Supplement with Pancreatin Digestive Enzymes Ox Bile & Betaine HCL - Ox Bile Supplements for No Gallbladder & Digestive Health,” also available on AMAZON. Overall, I feel less sluggish. To be honest, the potential anti-aging benefits are a big motivation for me taking this supplement. Only time will tell the effectiveness. In the meantime, I will remain satisfied with extra energy.
V**C
I don’t like
After I started taking these pills, my stomach began to hurt and I started feeling unwell; I was forced to stop taking them. I also experienced pain in the right side of my abdomen that felt similar to liver pain.
D**T
top of the line
This is a methylated supplement that includes 1000 mcg of methylated folate and B6. These capsules are acid resistant Enteric capsules that survive the acidic environment of the stomach, releasing their payload only in the alkaline environment of the small intestine for maximum uptake.
D**R
Great Ingredients! Great brand!
This is TMG Methylation Essentials (Trimethylglycine) supplement by RENUE By Science brand. RENUE By Science is a highly respected supplement brand that only uses the highest quality ingredients. Their products are made in the USA in an FDA inspected facility. They are cGMP compliant. This bottle has 120 acid resistant capsules which will last you two months. This supplement contains 900mg of TMG plus 2 mg Zinc, 1000 mcg Folate, 30 mcg B12, and 5.1 mcg B6, which work synergistically with TMG to support effective methylation pathways. This is a great supplement!
K**S
Good nutrition.
All good, the grouse product.
A**X
Works for me
Works really well for me
T**Y
First impressions not so good, but I will keep going and change more review if it gets better
Seem to be getting a high dose of brain fog for the first two days of taking this. I had a day off of it and felt better, I’m gonna take one tablet which is half a dose for the next few days and see how that goes. I’ve been told that maybe I should drink more water because I could be detoxing as a result of the good supplementation. In the past I’ve had seeking health kids multivitamin methylated and had zero issues so I’m not quite sure what’s going on with it.
Trustpilot
1 month ago
3 weeks ago