Doctor's BESTSAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

Incredibly productive! Really works! My mood has been really elevated, and has helped with my joint pain, will definitely be buying more.

Well it worked for me! I discovered Sam-e while doing some research on my own and decided to give it a try for my mild to moderate depression problems. It worked for me after about a week I started to notice a difference in my mood, I had more energy, and I was able to concentrate again. A few weeks after that i decided i didn't need it anymore and went off of it and a few days later I woke up feeling terrible with the same unpleasant feelings I had before I started taking it. Needless to say that night I went to the supermarket and bought some more. Now I just buy it from amazon because I know I need it and it offers the best value. I'll happily dish out forty bucks every two months if it helps me feel like this. I will note though that at first when I was switching brands I did have some gastrointestinal discomfort that was really unpleasant at first. It lasted off and on about three weeks, but then it stopped and I haven't had it since. I changed my diet to make sure I got about the same amount of fiber everyday to try and combat those problems and for me that seemed to work. I take one 400mg tablet every morning on an empty stomach and wait thirty minutes to an hour before eating anything. One time I ate something a few minutes after taking it and I did vomit so there's your warning, they actually do mean it when they say to wait to eat. Overall, I'm extremely happy with this product and if you don't believe these reviews look up some scholarly articles on it and the research speaks for itself, I believe they actually prescribe it for mild to moderate depression in countries like Germany. I've also read that st. john's wort works too for depression problems, but I've never tried it. A warning about st. john's though it can mess with the efficacy of birth control pills so I would be cautious about st. john's wort if you're taking birth control.

My doctor suggested I start taking SAM-E at 800mg twice a day (1600mg), as well as 5-HTP. She didn't mention that any one brand of Sam-e was better than any others, but that it spoiled quickly and I should get the kind sealed individually in blister foil. After looking at the crazy prices of other brands (I wish my insurance would cover it) I decided that I needed something cheap that I could take for a long time. So I tried Doctor's Best.I've done some research since then, and even though the Doctor's Best formulation isn't really 'the best' out there, it works. I'm sorry to hear that others aren't as responsive to this formulation, but for me, it's worked well enough for the value that I'll continue to purchase it.If I skip two days of Sam-e, I can tell that the depression starts to creep back in. Within an hour of taking 800mg Sam-e on an empty stomach, I'm back to normal. Compare this to SSRIs, where if I missed a single day, the next day I took a dose I'd be vomiting for hours and it would take another 6 days for the depression to subside.I wouldn't say that my depression is 'cured' per se, but I've found an economical (compared to different Sam-e brands) non-prescription, no side-effect way to effectively manage it. I am curious to try another formulation/brand, but for now, Doctor's Best has been working fine and I have been very impressed.

Great!

I’ve taken SAM-e for 2 decades now. I used to buy exclusively Nature Made and I like it but can’t seem to find it in the drugstores anymore where I used to get it BOGO frequently so I first tried this brand at Walmart and it was always pretty good. It’s one of only 3 that consumer lab recommended in their paid report. Anyone trying SAM-e its best to get it 2-2.5 years before the expiration date, in a blister pack, enteric coated, on an empty stomach and with folic acid, b6 & b12. This one checks all the boxes at a very good price. Not all SAM-e supplements have the amount they claim. I haven’t had issue with this brand. For mood you generally need about 1200-1600 mg a day to deal with any significant depression. The only reason it isn’t a drug (since it works better than most pharmaceuticals) is that it’s naturally occurring and not patentable. So it’s an expensive supplement instead. But I highly recommend it. And I only like this one or Nature Made or Natures Bounty (but I can’t find it anymore). Natures Trove is okay in a pinch but I think this might be the best of the less expensive brands.