---
product_id: 3403144
title: "Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses"
brand: "frontline"
price: "4378947₫"
currency: VND
in_stock: true
reviews_count: 12
category: "Frontline"
url: https://www.desertcart.vn/products/3403144-plus-for-dogs-large-dog-45-to-88-pounds-flea
store_origin: VN
region: Vietnam
---

# Waterproof after 24 hours Month-long protection per dose Fast-acting in 24 hours Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses

**Brand:** frontline
**Price:** 4378947₫
**Availability:** ✅ In Stock

## Summary

> 🐾 Stay ahead of pests with Frontline Plus — because your dog deserves the best!

## Quick Answers

- **What is this?** Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses by frontline
- **How much does it cost?** 4378947₫ with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.vn](https://www.desertcart.vn/products/3403144-plus-for-dogs-large-dog-45-to-88-pounds-flea)

## Best For

- frontline enthusiasts

## Why This Product

- Trusted frontline brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Waterproof Shield:** Protection stays effective even after your dog gets wet
- • **Effortless Monthly Care:** Easy single-spot application for 30 days of coverage
- • **Tailored for Large Dogs:** Specifically formulated for dogs 45-88 lbs for optimal dosing
- • **Trusted for Over 20 Years:** Proven reliability with millions of happy pets worldwide
- • **Rapid Relief, Lasting Defense:** Kills fleas, ticks, lice, mites & eggs within 24 hours

## Overview

Frontline Plus for Large Dogs delivers fast, waterproof flea and tick protection that kills adult pests and their eggs for a full month. Trusted for over 20 years, this easy-to-apply topical treatment is specially formulated for dogs weighing 45 to 88 pounds, ensuring comprehensive, long-lasting defense against infestations and the diseases ticks carry.

## Description

Product Description Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention. Brand Story By Frontline Plus

Review: Finally found something that actually works! - After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs!
Review: Works good - Works good. Been using for 4-5 years. My German shepherd has no problems with its use. No stinking smell. Effective my dog doesn’t scratch. Easy to apply. Recommended

## Features

- Provides fast-acting, long-lasting flea and tick protection for pets 8 weeks or older
- Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae
- Waterproof 24 hours after application
- Easy to apply for once a month for lasting protection
- For best results, apply every month

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0002J1FOO |
| ASIN  | B0002J1FOO |
| Age Range Description | All Life Stages |
| Best Sellers Rank | #264 in Pet Supplies ( See Top 100 in Pet Supplies ) #2 in Dog Flea Drops |
| Brand Name | Frontline |
| Breed Recommendation | Large Dog, 45 to 88 pounds |
| Color | Purple Box |
| Country of Origin | United States |
| Customer Reviews | 4.4 4.4 out of 5 stars (49,623) |
| Date First Available | October 2, 2001 |
| Date First Available  | October 2, 2001 |
| Department | Pet Supplies |
| Department  | Pet Supplies |
| Directions | Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze… |
| Included Components | Package includes 6 applicators |
| Is Discontinued By Manufacturer  | No |
| Item Dimensions LxWxH | 5.75 x 1 x 4.5 inches |
| Item Package Dimensions L x W x H | 5.8 x 4.41 x 1.06 inches |
| Item Weight | 0.2 Ounces |
| Item model number | 72219 |
| Item model number  | 72219 |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer  | Boehringer Ingelheim Animal Health |
| Manufacturer recommended age  | 1 month and up |
| Model Name | FRONTLINE Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses |
| Number of Items | 6 |
| Product Dimensions  | 5.75 x 1 x 4.5 inches; 0.2 ounces |
| Size | 6 Count |
| Specific Uses for Product | average |
| Style | Large Dog (45-88 lbs.) |
| Target Audience Keyword | ( reptiles | amphibians ), dogs, dogs|( reptiles | amphibians ) |
| Warranty Description | only for dogs |

## Product Details

- **Active Ingredients:** fipronil and (S)-methoprene
- **Age Range (Description):** All Life Stages
- **Allergen Information:** Abalone Free
- **Brand:** Frontline
- **Dog Breed Size:** Large
- **Item Form:** Liquid
- **Item Volume:** 1 Milliliters
- **Item Weight:** 0.2 Ounces
- **Scent:** Unscented

## Images

![Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses - Image 1](https://m.media-amazon.com/images/I/711CF6-d1KL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: effectiveness**
A: Ive never had a flea problem with frontline, but for ticks they would attach to the dog before it died. 
So i switched to the seresto 8 month collar. The 1st one i used worked great no issues. The 2nd one 
(8months later) had the same date as the first one. I dont know if that was an issue but the collar stopped working 
after 5 months and we ended up with fleas. First time that we ever had fleas. So i am going back to frontline. 
My concerns are the date on package and where its coming from.

**Q: can i use this on my cat?**
A: Hi,
Thank you for your question! This specific product and formula is only intended for large dogs and puppies 45 - 88 lbs and should not be applied to cats.
We have Frontline Plus for Cats 6 dose that is specifically formulated to treat your Cats & Kittens 1.5 lbs and above for 6 full months of protection.
If you have any additional questions, please call our experts at 1-800-660-1842.

**Q: how soon after use, can I bathe dog with shampoo**
A: "FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application. "I would also wait a few extra days if there are fleas in your carpet or if the dog is around bark dust because you can't reapply it if you wash it off prematurely.  I try to wait until I have vacuumed the house a few times.  Also, it takes a starving flea a couple of days to die.  I totally understand not wanting to touch that wet spot on puppy's neck. This is a small sacrifice. Good luck!  I am a firm believer in frontline.

**Q: is it a pill?**
A: No, this is a topical solution not a pill.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Finally found something that actually works!
*by R***Z on February 9, 2026*

After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs!

### ⭐⭐⭐⭐⭐ Works good
*by E***1 on March 2, 2026*

Works good. Been using for 4-5 years. My German shepherd has no problems with its use. No stinking smell. Effective my dog doesn’t scratch. Easy to apply. Recommended

### ⭐⭐⭐⭐⭐ This stuff works!
*by M***A on March 4, 2026*

This product gets the job done! My dogs have never had a flea or a tick while using this treatment. It's an excellent preventative. I've tried other treatments that just don't work, and I always come back to Frontline. It's easy to use. It is a little greasy when you first put it on, but that's to be expected, and it dries up by the next day.

## Frequently Bought Together

- Frontline Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses
- Frontline Plus for Dogs Medium Dog (23-44 pounds) Flea and Tick Treatment, 6 Doses
- Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 6 Treatments

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*Product available on Desertcart Vietnam*
*Store origin: VN*
*Last updated: 2026-03-24*