---
product_id: 13130437
title: "II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply"
brand: "k9 advantix"
price: "3341308₫"
currency: VND
in_stock: true
reviews_count: 9
category: "K9 Advantix"
url: https://www.desertcart.vn/products/13130437-ii-large-dog-vet-recommended-flea-tick-and-mosquito-treatment
store_origin: VN
region: Vietnam
---

# For dogs 21-55 lbs Waterproof after 24 hours Kills fleas in 12 hours II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply

**Brand:** k9 advantix
**Price:** 3341308₫
**Availability:** ✅ In Stock

## Summary

> 🐾 Protect your pup like a pro — no pests, no worries!

## Quick Answers

- **What is this?** II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply by k9 advantix
- **How much does it cost?** 3341308₫ with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.vn](https://www.desertcart.vn/products/13130437-ii-large-dog-vet-recommended-flea-tick-and-mosquito-treatment)

## Best For

- k9 advantix enthusiasts

## Why This Product

- Trusted k9 advantix brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Rapid Flea Elimination:** Kills fleas within 12 hours to stop infestations fast
- • **All-in-One Pest Defense:** Repels & kills fleas, ticks, mosquitoes, biting flies & lice
- • **Easy Spot-On Application:** Simple, multi-spot topical treatment for even coverage and comfort
- • **Waterproof & Fragrance-Free:** Lasts through baths and playtime without scent or residue
- • **Vet-Recommended & Prescription-Free:** Trusted formula available OTC for hassle-free protection

## Overview

K9 Advantix II Large Dog is a vet-recommended, topical flea, tick, mosquito, biting fly, and lice treatment designed for dogs weighing 21-55 lbs. It kills fleas within 12 hours and repels pests on contact, preventing bites and infestations. Waterproof after 24 hours and fragrance-free, it offers convenient monthly protection without a prescription, ensuring your dog stays pest-free indoors and outdoors.

## Description

K9 Advantix II Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die. Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia. That’s why K9 Advantix II Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use K9 Advantix II Large Dog.For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park.K9 Advantix II Large Dog is a trademark of Elanco or its affiliates.

Review: Worked well for Fluke - I recently moved from the cooler, mountainous region of SC to the warmer climate of middle GA to attend graduate school. I had been using Comfortis for two and half years on my dog, Fluke, without any problems. However, about two weeks ago, I felt a lump on her neck, and upon inspection, I discovered a tick. I began looking all over her body for more of these little pests, and found four more of them. Fortunately, Fluke is a rescue from a vet, and I don't have to bear the burden of expensive vet bills when something like this situation occurs. I was told that the Comfortis does not necessarily guard against ticks, and while it may have been effective in SC, the tick population in the heavily wooded river area in which I live now might be too much for the tablet to protect against for Fluke. I bought this product because it proffered to prevent ticks from attaching to the dog, and thus far, it has proven quite effective. Fluke, as her name suggests, is an unusual 25 pound lab/pit mixture. I purchased the product in the larger size because she is in between the medium and large dosing sizes, and I wanted to be sure that she had adequate protection. Fluke has been her usual happy self since I applied it to her. The directions indicated that you should apply in four to six spots on the dog, and I chose to apply to six, as to not have too high of a concentration in any area. I know that some people have reported having adverse reactions upon applying this product on their dogs, but I have noticed a trend in the reviews: most of the reviews are concerning smaller dogs. It might be that the formula is just too much for a smaller dog, but I'm not anywhere near an expert on the topic, just something that I have noticed. I am of the opinion that what it boils down to is this: all dogs are different, and what works well for one dog does not necessarily work well for others; the same could be said of medications for people, too. I'm just happy to have chosen a product that works well for Fluke. On another note, if you only need flea prevention, Comfortis is amazing, and much less messy than the topical products. While searching for more ticks, I never did find a flea on her! I hope that my review could be of some help, even though it is not very specific. UPDATE AS OF JULY 2013: I have brought home a 4 pound Pomeranian since my original post. I stand by what I stated in my previous post: this product works well for fleas, ticks, and mites in the warmer climate of middle Georgia in which I live. Barnaby, my little Pomeranian, has not had an adverse reaction to this medication, and Fluke, my lab/pit mixture, remains free of fleas and ticks, all the while not exhibiting any negative symptoms. For my little Pomeranian, I applied the medication to 4 separate places along his back, again to not have too high of a concentration in any one area. I purchased the smallest dose currently on the market, and although it was a little high for his small stature, it did not seem to phase him in any sort of negative ways. I wait, at a minimum, 72 hours before bathing my dogs, and I also do not bathe them for at least 5 days prior to application of the medication, as the oils within a dog's skin distribute the topical treatment. My dogs tolerate this medication well, and I have not found a flea or tick on either of them since I began using this product; however, I still will caution potential purchasers of this product: this product may not work well for your dog, just as some medications may not work well for you. Please, before you condemn the product as unsatisfactory, try to determine, and this may require the aid of a veterinarian, what your particular dog requires based upon breed, climate, and tolerance to topical flea prevention. I can only relate that this product works well for my larger dog and also my smaller dog within the area in which we currently live. Again, I hope that my update as to the effects of this product upon my smaller dog is helpful in your search for the right fit for your dog.
Review: Advantix 2 works great. It truly repels as advertised especially the mosquitos ... - Advantix 2 works great. It truly repels as advertised especially the mosquitos which is good since those are the thing to worry about heartworm. Frontline is getting tolerant, I always have far better results from Advantix 2. For anyone looking for full 4 weeks of perfect coverage, it just doesn't exist. Any topical solution will weaken as you near the 4th week but I have found Advantix 2 to be GREAT. This is a great Seller and cannot beat the price. This is my second time purchasing from this seller on desertcart for price but also quality of product not sold nearing expiration. Expiration doesn't MEAN BAD it means Weaker. OK... SO! What about Irritated Skin!? Don't BUY IT if your worried about that! Some dogs are extra sensitive or ALLERGIC. DONT buy a topical solution if that is a huge concern. IT DOESN'T MAKE THIS A 1 STAR product because your dog is allergic or sensitive. For god sakes, you are putting poison on them and that includes in any brand unless your getting a prescription for a Pill. Then there are other possible side effects. Accept That. Anything you choose has Pro and Con's. My dog has sensitive Skin. She will get a little pink when I use ANY topical solution. However Advantix 2 is well known for being kinda strong. So how do I manage it for my Furbaby??? Easy. Take the time to put the solution on in several places. NOT JUST ONE BLOB, because you're too lazy. I skip the base of the tail. I never understood this. My dog can lick there all she wants. But I go from base of head at the back of the skull and ever couple inches I squirt a little down till I get between the shoulder blades and even so much as a little bit below that on her back. This helps spread it out and not irritate her and make her itchy. Then again, my pup has allergies and she's on Zyrtec daily. But when I use to not spread it out she would seem uncomfortable, now she is fine with it. She is just sticky for a day. A Con is Advantix 2 is a little greasier and you get More of it. But frontline barely gives any and never seems to work past 2 weeks. So take your pick! After a day, I brush her out and there is no more sticky. I wait a week instead of 48 hours to bath her. I don't notice any lack of flea control after a bathing. I really think this product works for anyone in areas where Frontline is losing its effectiveness. Also, heartworm is a billion dollar scare tactic. The idea of it is terrifying however, it is also expensive and for anyone struggling to spend that kind of money per month on their pup. Or those who are concerned with the drug's effect on the body long term, or those that are allergic. Advantix 2 has that added benefit of the mosquito repellent if you're religious in your re-applications. So... yeah. You're going to see pictures of Poor Pink or Red skin. Statistically, there will ALWAYS be a % of animals that have an allergic reaction to inactive ingredients. However, as an owner of a dog with skin problems. Just be smart about spreading out the application and don't go putting detergents on your dog "washing it clean" because their skin got a little pink or irritated. THAT is what worsens the situation. And I have gone through skin and fur issues with my pup to know this. My dog is allergic to the grass. I know skin irritation. Or should I say She Knows.

## Features

- K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B004QMX4YW |
| ASIN  | B004QMX4YW |
| Age Range Description | 7 weeks and older |
| Best Sellers Rank | #637 in Pet Supplies ( See Top 100 in Pet Supplies ) #4 in Dog Flea Drops |
| Brand Name | K9 Advantix |
| Breed Recommendation | Large |
| Color | Large Dog only |
| Country of Origin | Germany |
| Customer Reviews | 4.4 4.4 out of 5 stars (43,643) |
| Date First Available | March 4, 2011 |
| Date First Available  | March 4, 2011 |
| Department | Unisex-Adult |
| Department  | Unisex-Adult |
| Directions | Application Instructions: 1. Use only on dogs. DO NOT USE ON CATS or other animals. 2. The dog should be standing for easy application. Evenly apply the entire contents of the K9 Advantix® II tube to four to six spots on the top of the back from the shoulder to the base of the tail. 3. At each spot, part the hair until the skin is visible. 4. Place the tip of the tube on the skin and gently squeez… |
| Is Discontinued By Manufacturer  | No |
| Item Dimensions LxWxH | 7.75 x 1 x 4.25 inches |
| Item Package Dimensions L x W x H | 5.16 x 4.45 x 1.46 inches |
| Item Weight | 1.44 ounces |
| Item model number | 86315041 |
| Item model number  | 86315041 |
| Manufacturer | Elanco US Inc |
| Manufacturer  | Elanco US Inc |
| Material | Plastic |
| Model Name | K9 Advantix II |
| Number of Items | 4 |
| Product Dimensions  | 7.75 x 1 x 4.25 inches; 1.44 ounces |
| Size | 4 Pack |
| Specific Uses for Product | Parasites |
| Style | Large Dog only |
| Target Audience Keyword | dogs |

## Product Details

- **Active Ingredients:** Imidacloprid, Permethrin, Pyriproxyfen
- **Age Range (Description):** 7 weeks and older
- **Allergen Information:** Allergen-Free
- **Brand:** K9 Advantix
- **Dog Breed Size:** Large
- **Item Form:** Topical
- **Item Volume:** 10 Milliliters
- **Item Weight:** 1.44 ounces
- **Scent:** Unscented
- **UPC:** 724089203991

## Images

![II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply - Image 1](https://m.media-amazon.com/images/I/71U+2ITgYeL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: I am thinking about ordering a 6 pack which some would be kept for next year. How do I know what the date is on the product?**
A: I looked everywhere on the individual package of the tubes and the box, there is nothing that mentions an expiration or use by date. There are phone numbers to call for questions...1-800-255-6826. Looking at how the tubes are packaged, my best guess would be that as long as they are sealed properly and not opened you could probably use unopened tubes at a later time. I have 2 dogs and ordered the six pack myself, if I don't use give my girls all 3 of their doses this year I will probably use it up next summer then.

**Q: What is the expiration date on this $41 product currently for sale???**
A: The expiration date is usually stamped into the package. And $41 is very good price for k9 Advantix II. It's often quite more expensive from your vet or other sites.

**Q: Is this safe for sight hounds and/or dogs over the age of 12? Thank you for taking time to answer.**
A: Yes, there should be no issue when using on a sight hound.  I use this on my Brittney with no issues.  Be advised this does not " repel" ticks.  Ticks will still get onto your dog and can/will bite however, the tick will be impaired/ killed over a few hours time after biting.  When used with a organic spray for Ticks you should have no issues.  I have never had a flea on my dog nor my 2 cats. I recommend this product fully.  Be sure to match your dog's weight with the correct Advantix.

**Q: Does it send all 6 doses at a time?**
A: When you order a 6 pack that means 6 doses.  IF you order a 3 or 4 pack.  it is that many doses respectively.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Worked well for Fluke
*by A***N on April 29, 2012*

I recently moved from the cooler, mountainous region of SC to the warmer climate of middle GA to attend graduate school. I had been using Comfortis for two and half years on my dog, Fluke, without any problems. However, about two weeks ago, I felt a lump on her neck, and upon inspection, I discovered a tick. I began looking all over her body for more of these little pests, and found four more of them. Fortunately, Fluke is a rescue from a vet, and I don't have to bear the burden of expensive vet bills when something like this situation occurs. I was told that the Comfortis does not necessarily guard against ticks, and while it may have been effective in SC, the tick population in the heavily wooded river area in which I live now might be too much for the tablet to protect against for Fluke. I bought this product because it proffered to prevent ticks from attaching to the dog, and thus far, it has proven quite effective. Fluke, as her name suggests, is an unusual 25 pound lab/pit mixture. I purchased the product in the larger size because she is in between the medium and large dosing sizes, and I wanted to be sure that she had adequate protection. Fluke has been her usual happy self since I applied it to her. The directions indicated that you should apply in four to six spots on the dog, and I chose to apply to six, as to not have too high of a concentration in any area. I know that some people have reported having adverse reactions upon applying this product on their dogs, but I have noticed a trend in the reviews: most of the reviews are concerning smaller dogs. It might be that the formula is just too much for a smaller dog, but I'm not anywhere near an expert on the topic, just something that I have noticed. I am of the opinion that what it boils down to is this: all dogs are different, and what works well for one dog does not necessarily work well for others; the same could be said of medications for people, too. I'm just happy to have chosen a product that works well for Fluke. On another note, if you only need flea prevention, Comfortis is amazing, and much less messy than the topical products. While searching for more ticks, I never did find a flea on her! I hope that my review could be of some help, even though it is not very specific. UPDATE AS OF JULY 2013: I have brought home a 4 pound Pomeranian since my original post. I stand by what I stated in my previous post: this product works well for fleas, ticks, and mites in the warmer climate of middle Georgia in which I live. Barnaby, my little Pomeranian, has not had an adverse reaction to this medication, and Fluke, my lab/pit mixture, remains free of fleas and ticks, all the while not exhibiting any negative symptoms. For my little Pomeranian, I applied the medication to 4 separate places along his back, again to not have too high of a concentration in any one area. I purchased the smallest dose currently on the market, and although it was a little high for his small stature, it did not seem to phase him in any sort of negative ways. I wait, at a minimum, 72 hours before bathing my dogs, and I also do not bathe them for at least 5 days prior to application of the medication, as the oils within a dog's skin distribute the topical treatment. My dogs tolerate this medication well, and I have not found a flea or tick on either of them since I began using this product; however, I still will caution potential purchasers of this product: this product may not work well for your dog, just as some medications may not work well for you. Please, before you condemn the product as unsatisfactory, try to determine, and this may require the aid of a veterinarian, what your particular dog requires based upon breed, climate, and tolerance to topical flea prevention. I can only relate that this product works well for my larger dog and also my smaller dog within the area in which we currently live. Again, I hope that my update as to the effects of this product upon my smaller dog is helpful in your search for the right fit for your dog.

### ⭐⭐⭐⭐⭐ Advantix 2 works great. It truly repels as advertised especially the mosquitos ...
*by E***E on March 14, 2015*

Advantix 2 works great. It truly repels as advertised especially the mosquitos which is good since those are the thing to worry about heartworm. Frontline is getting tolerant, I always have far better results from Advantix 2. For anyone looking for full 4 weeks of perfect coverage, it just doesn't exist. Any topical solution will weaken as you near the 4th week but I have found Advantix 2 to be GREAT. This is a great Seller and cannot beat the price. This is my second time purchasing from this seller on Amazon for price but also quality of product not sold nearing expiration. Expiration doesn't MEAN BAD it means Weaker. OK... SO! What about Irritated Skin!? Don't BUY IT if your worried about that! Some dogs are extra sensitive or ALLERGIC. DONT buy a topical solution if that is a huge concern. IT DOESN'T MAKE THIS A 1 STAR product because your dog is allergic or sensitive. For god sakes, you are putting poison on them and that includes in any brand unless your getting a prescription for a Pill. Then there are other possible side effects. Accept That. Anything you choose has Pro and Con's. My dog has sensitive Skin. She will get a little pink when I use ANY topical solution. However Advantix 2 is well known for being kinda strong. So how do I manage it for my Furbaby??? Easy. Take the time to put the solution on in several places. NOT JUST ONE BLOB, because you're too lazy. I skip the base of the tail. I never understood this. My dog can lick there all she wants. But I go from base of head at the back of the skull and ever couple inches I squirt a little down till I get between the shoulder blades and even so much as a little bit below that on her back. This helps spread it out and not irritate her and make her itchy. Then again, my pup has allergies and she's on Zyrtec daily. But when I use to not spread it out she would seem uncomfortable, now she is fine with it. She is just sticky for a day. A Con is Advantix 2 is a little greasier and you get More of it. But frontline barely gives any and never seems to work past 2 weeks. So take your pick! After a day, I brush her out and there is no more sticky. I wait a week instead of 48 hours to bath her. I don't notice any lack of flea control after a bathing. I really think this product works for anyone in areas where Frontline is losing its effectiveness. Also, heartworm is a billion dollar scare tactic. The idea of it is terrifying however, it is also expensive and for anyone struggling to spend that kind of money per month on their pup. Or those who are concerned with the drug's effect on the body long term, or those that are allergic. Advantix 2 has that added benefit of the mosquito repellent if you're religious in your re-applications. So... yeah. You're going to see pictures of Poor Pink or Red skin. Statistically, there will ALWAYS be a % of animals that have an allergic reaction to inactive ingredients. However, as an owner of a dog with skin problems. Just be smart about spreading out the application and don't go putting detergents on your dog "washing it clean" because their skin got a little pink or irritated. THAT is what worsens the situation. And I have gone through skin and fur issues with my pup to know this. My dog is allergic to the grass. I know skin irritation. Or should I say She Knows.

### ⭐⭐⭐⭐⭐ Love this stuff!
*by C***N on January 27, 2026*

Very happy with the results every time. I have used this for years on my dogs and never see fleas or ticks on them! I'll never use anything else.

## Frequently Bought Together

- K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply
- K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 4-Mo Supply
- K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 4-Mo Supply

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*Product available on Desertcart Vietnam*
*Store origin: VN*
*Last updated: 2026-02-11*